Circulating levels of tumour necrosis factor-α & interferon-γ in patients with dengue & dengue haemorrhagic fever during an outbreak


Background & objectives: Dengue haemorrhagic fever (DHF) is a severe illness caused by dengue viruses, the pathogenesis of which is not fully understood. Immune enhancement caused by cytokines, interferon and activated complement system is one of the hypotheses proposed to explain the haemorrhagic form of disease. This study was undertaken to investigate the role of pro-inflammatory cytokines tumour necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in dengue infection, and their possible association with disease severity.


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