YB-1 (YBX1) does not bind to Y/CCAAT boxes in vivo

Abstract

YB-1 (Y box binding protein-1) is an oncogene, overexpressed in cancers and believed to mediate drug resistance. It was originally identified as one of the proteins binding to the Y/CCAAT box, and later shown to bind to multiple, normal and altered, nucleic acids (RNA and DNA). The YB-1 role in the control of mRNA biology— stability, splicing, translation—is established, while its function as a transcriptional activator is more controversial, particularly

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